AMRS001
AMRS001, also known as MANF, is a highly potent, neurotrophic factor currently in pre-clinical development for the treatment of several apoptosis-related disorders. Coming after other selective neurotrophic factors such as GDNF, Neurturin, NGF, and others, AMRS001′s discovery protocols, utilizing our proprietary PhenoGuard Protein Discovery Engine were designed to identify a molecule that would be highly selective for dopamine producing neurons of the Substantia Nigra. AMRS001 represents a new family of neurotrophic factors with mechanisms of action fundamentally differentiated from its predecessors.
AMRS001 is an endogenous, highly-conserved, ubiquitously expressed and highly potent secreted human growth factor up-regulated in the adaptive pathway of the Unfolded Protein Response resulting in the prevention of apoptosis. This cell death is associated with several devastating human diseases and injury related disorders. By mediating this critical biological process, AMRS001 is highly indicated for the treatment of several poorly served medical conditions, including Parkinson’s disease, Ischemic Heart Disease and Organ Transplantation.